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In the new study, Lowery's team found that the test they've developed can reliably detect the five most common species of Candida within about three hours.
NortonWEDNESDAY, April 24 (HealthDay News) An experimental test could help doctors catch a deadly type of fungal infection in the blood within a few hours, rather than the few days it currently takes, a new study suggests.
The symptoms of candidemia are vague, and include fever and chills, so doctors use blood cultures to diagnose it. That means putting a blood sample in a special broth that feeds the yeast organism until it grows enough to be detected.
According to Lowery's team, research suggests that with Candida infections, starting the right antifungal drug within 12 hours can cut the death rate from 40 percent to 11 percent.
The researchers used blood samples from healthy people and "spiked" them with Candida yeast. They then analyzed the samples with the new test and with standard blood cultures. The two tests were in agreement on "positives" 98 percent of the time.
Lowery said that if the test gets more patients on the right drug quickly, the cost would likely be worth it.
The process would also need to be automated, she noted, to be feasible for smaller community hospitals. T2 Biosystems' Lowery said the researchers are working on making the method "fully automated."
Getting a precise diagnosis is vital, Lowery said, both to confirm that it's Candida, and to pinpoint which type it is. "You need to know the specific Candida so you can use the right antifungal drug," he said.
By that time, it may be too late for the patient. About 40 percent of people with Candida blood infections die, and delayed diagnosis bears part of the blame, Lowery and Nike Air Vapormax Black Mens his colleagues write in the April 24 issue of the journal Science Translational Medicine.
"Now you'd like to see this tested in a larger, multicenter trial," Ginocchio said.
What's particularly "exciting" is that the technology could potentially be used to test for other pathogens that cause serious bloodstream infections, according to Ginocchio, who is also a member of the Infectious Diseases Society of America's Diagnostics Task Force.
The new test, which is based on so called magnetic resonance technology, essentially removes the "noise" coming from other material in the blood sample, allowing it to zero in on the pathogen.
The test, which is not yet on the market, looks for Candida infection in the blood. The fungus is best known for causing common vaginal yeast infections, but when it gets into the bloodstream it can cause serious infections of organs and tissue throughout the body. Centers for Disease Control and Prevention.
But Candida "is a slow grower," and it takes a few days to get blood culture results back, said Thomas Lowery of T2 Biosystems, the Lexington, Mass. based company developing the new test.
Blood Test May Catch Deadly Fungal Infection Quickly
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Ideally, Ginocchio explained, when doctors suspect a patient has a bloodstream infection, they would be able to take a blood sample, directly test it, then have a result in a few hours. The problem right now is that a blood sample would normally not contain enough of the culprit bug be it a fungus or bacterium to detect.
Plus, Ginocchio noted, the blood contains a lot of other genetic material that gets in the way of spotting that bit of foreign invader DNA. That's why blood cultures are done.
The infection is typically transmitted through contaminated catheters, and seen in seriously ill patients such as those in the intensive care unit, or with weakened immune systems.
Exactly what it would all cost is not known. But both Ginocchio and Nike Vapormax Flyknit College Navy
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